Dysplastic nevus - Dysplastesche Nevus
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Dysplastic nevi ― Biopsie gëtt fir Westerner recommandéiert.
relevance score : -100.0%
ReferencesDysplastic nevus, och bekannt als atypesch (atypical) oder Clark's nevus, huet Debatten an der Dermatologie an der Dermatopathologie ausgeléist. Dokteren Biopsie dacks dës Mole well se anormal ausgesinn a Bedenken iwwer Melanom erhéijen.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
A dysplastic nevus is also referred to as an atypical or Clarks nevus and has been the topic of much debate in the fields of dermatology and dermatopathology. It is an acquired mole demonstrating a unique clinical and histopathologic appearance that sets it apart from the common nevus. These moles appear atypical clinically, often with a fried-egg appearance, and are commonly biopsied by providers due to the concern for melanoma.
Dysplastesche Nevi, och bekannt als atypesch (atypical) oder Clark‑Nevi (Clark's nevus), kann heiansdo zu Melanom féieren. Ongeféier 36 % vun de Melanome gi bei dysplastesche Nevi fonnt. Zeechen (signs), datt en dysplastesche Nevus zu Melanom verwandelen kann, enthalen ongläich Form, méi Pigmentännerungen oder eng grouss Faarf. Dës Krebserkrankungen (cancers) geschéien normalerweis an engem méi jonken Alter (rond d'Mëtt vun den Drëssegjärege), kënne multiple sinn a sinn dacks um Stamm. Genetesch sinn dysplastesche Nevi tëscht benigne (benign) Nevi an Melanom. Allerdéngs kommen nëmmen 20 % bis 30 % vun de Melanome aus existéierenden Nevi. Well déi meescht Nevi kee Melanom ginn, ass et normalerweis net recommandéiert, se präventiv ze läschen.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
Dysplastic nevus, also called atypical or Clark nevus, can be precursor to melanoma, as the observation that 36% of melanomas have dysplastic nevi near the invasive tumor supports. Signs that a dysplastic nevus may have transitioned into a melanoma include asymmetry in contour, a noticeable increase in pigment variations, or a grayish tint indicating regression. These malignancies typically arise at a younger age (mid-thirties), are sometimes multiple, and are often found on the trunk. Molecularly, dysplastic nevi have a profile intermediate between benign nevi and malignant melanoma. While there is a recognized connection between dysplastic nevi and melanoma, it’s crucial to note that only about 20% to 30% of melanomas evolve from preexisting nevi. Given that the majority of dysplastic and typical nevi do not develop into melanoma, preventive removal of melanocytic nevi is not typically advised.
E Melanom ass eng Zort Tumor, déi sech formt wann Melanocyten (melanocytes), Zellen verantwortlech fir Hautfaarf, kriibserreegend ginn. Melanocyten (melanocytes) entstinn aus dem neuralen Kamm. Dëst bedeit datt Melanome sech net nëmmen op der Haut entwéckelen kënnen, awer och an anere Beräicher, wou neural Kammzellen migréieren, wéi de Magen‑Darmtrakt an Gehir. D'Iwwerliewensquote fir Patiente mat Melanom (Stadium 0) ass héich bei 97 %, während se wesentlech op ongeféier 10 % fällt fir déi diagnostizéiert mat fortgeschrattene Stadium (Stadium IV).
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
A melanoma is a tumor produced by the malignant transformation of melanocytes. Melanocytes are derived from the neural crest; consequently, melanomas, although they usually occur on the skin, can arise in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain. The five-year relative survival rate for patients with stage 0 melanoma is 97%, compared with about 10% for those with stage IV disease.
○ Kriibsrisiko (cancer risk)
Wéi bei kaukaseschen (Caucasian) Individuen an den USA gesi ginn, hunn déi mat dysplastesche Nevi e Liewensdauer Risiko fir Melanom (melanoma) vu méi wéi 10 % z'entwéckelen. Op der anerer Säit hunn déi ouni dysplastesche Nevus e Risiko fir Melanom (melanoma) vu manner wéi 1 % z'entwéckelen.
○ Precaution (precaution) fir Individuen mat dysplasteschen Nevi
Haut Selbstuntersuchung (skin self‑examination) gëtt normalerweis empfohlen fir Melanom (melanoma) ze vermeiden (duerch d'Identifikatioun vun atypical Nevi, déi ewechgeholl kënne ginn) oder fir fréizäiteg Detektioun vun existente Tumoren. Leit mat enger perséinlecher oder familiärer Geschicht vu Hautkriibs oder vu multiplen atypical Nevi sollten op d'mannst eemol d'Joer en Dermatologe gesinn fir sécher ze sinn datt se kee Melanom (melanoma) entwéckelen.
D'Ofkierzung [ABCDE] war nëtzlech fir Gesondheetsversuerger a Laie ze hëllefen d'Schlësselcharakteristike vun engem Melanom (melanoma) z'erënneren. Leider fir déi duerchschnëttlech Persoun, vill Seborrheesch Keratosen (seborrheic keratoses), e puer lentigo senilis, a souguer Warzen (warts) kënnen [ABCDE] Charakteristiken hunn, a kënnen net vun engem Melanom (melanoma) ënnerscheeden.
○ [ABCDE]
Asymmetrical: asymmetrësch (asymmetrical).
Border: D'Grenz (border) vun der Läsion ass onregelméisseg.
Color: Melanome weisen normalerweis méi onregelméisseg Faarwen (color).
Diameter (diameter): Nevi méi wéi 6 mm si méi wahrscheinlech Melanome (melanomas) wéi méi kleng Nevi.
Evolution (evolution): D'Evolutioun (dh Ännerung) vun engem Nevus oder Läsion kann uginn datt d'Läsioun bösarteg gëtt.